Rapid Review: Acanthosis Nigricans
Reviewed February 2024
Acanthosis Nigricans
- Risk factors: obesity, diabetes, rarely malignancy
- PE: thickened, velvety, darkly pigmented plaques on the neck or axillae
- Screen for diabetes and treat underlying disorder
Sample question:
A 39-year-old woman presents for evaluation of darkening areas on the back of her neck. She has a history of hypertension and hypothyroidism. Her current medications include oral contraceptives, levothyroxine 125 mcg, and lisinopril 10 mg. Her vital signs are body mass index of 35.2 kg/m2, temperature of 97.7°F, blood pressure of 140/98 mm Hg, heart rate of 97 bpm, respiratory rate of 18/minute, and oxygen saturation of 100%. Physical exam reveals hyperpigmented plaques with a velvety appearance on the back of her neck and her bilateral axilla. Her hemoglobin A1C is 5.5 mg/dL. What component of the patient’s history is the most commonly associated with her skin findings?
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