Rapid Review: Multiple Myeloma

Multiple Myeloma

• Patient will be elderly
• Complaining of back pain
• PE will show CRAB: hyperCalcemia, Renal insufficiency, Anemia, lytic Bone lesions/Back pain
• Labs will show monoclonal antibody spike
• X-ray will show lytic lesions
• Peripheral blood smear: Rouleaux formations
• Serum protein electrophoresis: M spike
• Protein electrophoresis urine analysis: Bence-Jones proteins
• Most commonly caused by single clone plasma cell malignancy