Rapid Review: Myasthenia Gravis

June 19, 2017
Myasthenia gravis
  • Patient will be complaining of proximal muscle weakness, ptosis, and diplopia that is worse at the end of the day
  • PE will show ice test improves sx
  • Diagnosis is made by edrophonium (tensilon) test, EMG
  • Most commonly caused by autoimmune destruction of acetylcholine receptors
  • Treatment is acetylcholinesterase inhibitors, such as pyridostigmine
  • Comments: associated with thymoma

Example: A 28-year-old woman presents with complaints of double vision and fatigue. These symptoms are generally better in the morning and progress throughout the day. She works long hours and says toward the end of her shift she is extremely fatigued and has difficulty completing her tasks. Which of the following is the most likely etiology?

By Yehuda Wolf, MPA, PA-C

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