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Each question is written to resemble the format and topics on the exam, meaning you won’t see any negatively phrased questions, no “all of the following except,” no “A and B”…you know what we mean. Most importantly, all questions include selective distractors (incorrect answer choices), which will help you think critically.
An 18-year-old man presents to the hematology clinic for a follow-up. He has a history of sickle cell disease and is currently taking hydroxyurea. He is tolerating the hydroxyurea at maximum dose without side effects, but in the past year, he has been hospitalized six times for acute pain episodes involving his left arm and right leg. These pain episodes resolved after treatment with opioids and hydration. Other than sickle cell disease, he has no significant medical conditions. On vital signs, he has a T of 98.3°F, HR of 78 bpm, BP of 120/70 mm Hg, RR of 15/min, and SpO2 of 98%. The physical exam is unremarkable. Which of the following is the most appropriate next step in management?
Understanding why an answer choice is incorrect is just as important as knowing why one is correct. That’s why every Rosh Review question includes detailed explanations for the correct and incorrect answer choices. These comprehensive summaries link the most important components of a topic—from risk factors to diagnostics and treatment—giving you the context to build relationships between them.
Custom illustrations and tables help further clarify the core concepts. When information is presented visually, you can focus on meaning, easily reorganize and group similar ideas, and make better use of your memory.
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After each explanation is a straightforward question with a simple, memorizable answer that reinforces the corresponding topic.
Why do patients with sickle cell disease typically have increased susceptibility to bacterial infections?
Sickle Cell Disease
These bulleted reviews focus on condensed, high-yield concepts about the main topic, from patient presentation to preferred management.
The finest people around! Questions writers and content editors are board-certified clinicians who have all performed well on their examinations. Answer explanations are derived from the specialty's authoritative resources with some personal input to simply the material and synthesize it for greatest comprehension and recall.
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Matthew DeAugustinis, MD
Attending Physician